Revista nº 821

Consecuencias en la clínica de la inactivación del cromosoma X | Martín Hernández A. 30 Actual Med.2025;110(821):2 2-30 33. Youness A, Miquel C, Guéry J. Escape from X Chromo - some Inactivation and the Female Predominance in Au - toimmune Diseases. International Journal of Molecular Sciences 2021;22(3). 34. Gal-Oz S, Shay T. Genetics of Sex Differences in Immu - nity. In: Klein SL, Roberts CW, editors. Sex and Gender Differences in Infection and Treatments for Infectious Diseases Cham: Springer International Publishing; 2023. p. 1-19. 35. Miquel C, Faz-Lopez B, Guéry J. Influence of X chromo - some in sex-biased autoimmune diseases. J Autoimmun 2023;137:102992. 36. Sierra I, Anguera MC. Enjoy the silence: X-chromosome inactivation diversity in somatic cells. Curr Opin Genet Dev 2019;55:26-31. 37. Antonia Hauth, Jasper Panten, Emma Kneuss, Chris - tel Picard, Nicolas Servant, Isabell Rall, et al. Escape from X inactivation is directly modulated by levels of Xist non-coding RNA. bioRxiv 2024:2024.02.22.581559 [Preprint]. 2024 [citado 24 de abril de 2024]. doi: 10.1101/2024.02.22.581559 38. Richart L, Picod-Chedotel M, Wassef M, Macario M, Aflaki S, Salvador MA, et al. XIST loss impairs mammary stem cell differentiation and increases tumorigenicity through Mediator hyperactivation. Cell 2022;185(12):2164-2183. e25. 39. Yildirim E, Kirby JE, Brown DE, Mercier FE, Sadreyev RI, Scadden DT, et al. Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice. Cell 2013;152(4):727-742. 40. Wang D, Tang L, Wu Y, Fan C, Zhang S, Xiang B, et al. Abnor - mal X chromosome inactivation and tumor development. Cellular and Molecular Life Sciences 2020;77(15):2949- 2958. 41. Pluripotent stem cell [Internet]. Nature portfolio- Na- ture. 2024. [Citado 2 de mayo de 2024]. Recuperado a partir de: https://www.nature.com/subjects/pluripo - tent-stem-cells 42. Carrette LLG, Wang C, Wei C, Press W, Ma W, Kelleher RJ, et al. A mixed modality approach towards Xi reac - tivation for Rett syndrome and other X-linked disor - ders. Proceedings of the National Academy of Sciences 2018;115(4):E668-E675. Si desea citar nuestro artículo: Martín Hernández A. Mecanismos de inactivación del cromosoma X. Implicaciones y consecuencias clínicas. Actual Med.2025;110(821): 2 2-30 . DOI:10.15568/am.2025.82 1.rev02