34 / 68
92
Jose A. Lopez-Escamez
La herencia en los acúfenos
18. Lasisi AO, Abiona T, Gureje O. Tinnitus in the elderly: Profile,
correlates, and impact in the Nigerian Study of Ageing.
Otolaryngol Head Neck Surg. 2010; 143: 510-5.
19. Michikawa, T., Nishiwaki, Y., Kikuchi, Y., et al. Prevalence and
factors associated with tinnitus: a community-based study
of Japanese elders. J Epidemiol 2010; 20: 271-6.
20. Kvestad E, Czajkowski N, Engdahl B, Hoffman HJ, Tambs K.
Low heritability of tinnitus: results from the second Nord-
Trondelag health study. Arch Otolaryngol Head Neck Surg.
2010;136: 178-82.
21. Flores-Alfaro E, Burguete-García AI, Salazar-Martínez E.
Diseños de investigación en epidemiología genética. Rev
Panam Salud Publica. 2012; 31: 88–94
22. Kleinjung T, Langguth B, Fischer B, Hajak G, Eichhammer P,
Sand P G. Systematic screening of the seratonin receptor 1A
(5-HT1A) gene in chronic tinnitus. J Otol. 2006; 1: 83–5.
23. Deniz M, Bayazit YA, Celenk F, , et al. Significance of
serotonin transporter gene polymorphism in tinnitus. Otol
Neurotol. 2010; 31: 19–24.
24. Pawełczyk M, Rajkowska E, Kotyło P, Dudarewicz A, Van
Camp G,Śliwińska-Kowalska M. Analysis of inner ear
potassium recycling genes as potential factors associated
with tinnitus. Int J Occup Med Environ Health 2012; 25:
356–64.
25. Orenay-Boyacioglu S, Coskunoglu A, Caki Z, Cam FS.
Relationship between chronic tinnitus and glial cell line-
derived neurotrophic factor gene rs3812047, rs1110149, and
rs884344 polymorphisms in a Turkish Population. Biochem
Genet. 2016; 54: 552–63.
26. Yüce S, Sancakdar E, Bağci G et al. Angiotensin-Converting
Enzyme (ACE) I/D and Alpha-Adducin (ADD1) G460W gene
polymorphisms in Turkish Patients with severe chronic
tinnitus. J Int Adv Otol. 2016; 12: 77–81.
27. Bogo R, Farah A, Karlsson KK, Pedersen NL, Svartengren
M., Skjonsberg A. Prevalence, Incidence Proportion, and
Heritability for Tinnitus: A Longitudinal Twin Study. Ear Hear.
2017; 38: 292–300.
28. Maas I, Brüggemann P, Requena T, et al. Genetic
susceptibility to bilateral tinnitus in a Swedish twin cohort.
Genet Med. 2017 (in press).
29. Lichtenstein P, De Faire U, Floderus B, Svartengren M,
Svedberg P, Pedersen NL. The Swedish Twin Registry: a
unique resource for clinical, epidemiological and genetic
studies. J Intern Med 2002; 252: 184-205.
30. Pedersen NL, Lichtenstein P, Svedberg P. The Swedish Twin
Registry in the third millennium. Twin Res. 2002; 5, 427-32.
31. van Dongen J, Slagboom PE, Draisma HH, Martin NG,
Boomsma DI. The continuing value of twin studies in the
omics era. Nat Rev Genet. 2012;13, 640-53.
32. Requena T, Cabrera S, Martin-Sierra C, Price SD, Lysakowski
A, Lopez-Escamez JA. Identification of two novel mutations
in FAM136A and DTNA genes in autosomal-dominant familial
Meniere’s disease. Hum Mol Genet. 2015; 24: 1119–26.
33. Martín-Sierra C, Requena T, Frejo L, et al. A novel missense
variant in PRKCB segregates low-frequency hearing loss in
an autosomal dominant family with Meniere’s disease. Hum
Mol Genet. 2016; 25: 3407–15.
34. Martín-Sierra C, Gallego-Martinez A, Requena T, Frejo L,
Batuecas-Caletrio A, Lopez-Escamez JA. Variable expressivity
and genetic heterogeneity involving DPT and SEMA3D genes
in autosomal dominant familial Meniere’s disease. Eur J
Hum Genet. 2017; 25: 200–7
35. Cederroth CR, Canlo B, Langguth B. Hearing loss and
tinnitus--are funders and industry listening? Nat Biotechnol.
2013; 31: 972-4.
36. Espinosa-Sanchez JM, Heitzmann-Hernandez T, Lopez-
Escamez JA. Tratamiento farmacológico de los acúfenos:
mucho ruido y pocas nueces. Rev Neurol. 2014; 59: 164–74.