

64
Felipe Alconchel-Gago
Enfermedad de Huntington y ácido oleico
13. Túnez I, Tasset I, Pérez-De La Cruz V, Santamaría A.
3-Nitropropionic acid as a tool to study the mechanisms
involved in Huntington’s disease: past, present and future.
Molecules. 2010; 15: 878-916.
14. Cicerale S, Lucas LJ, Keast RS. Antimicrobial, antioxidant and
anti-inflammatory phenolic activities in extra virgin olive oil.
Curr Opin Biotechnol. 2012; 23: 129-35.
15. Féart C, Samieri C, Rondeau V, et al. Adherence to a
Mediterranean diet, cognitive decline, and risk of dementia.
JAMA. 2009; 302: 638-48.
16. Quiles JL, Ochoa JJ, Ramirez-Tortosa C. Dietary fat type (virgen
olive vs. Sunflower oils) affects age-related changes in DNA
double-strand-breaks, antioxidant capacity and blood lipids in
rats. Exp Gerontol. 2004; 39: 1189-98.
17. Geelings A, López-Huertas E, Morales JC, Boza J, Jiménez
J, inventors. Natural products and derivatives thereof for
protection against neurodegenerative diseases. US patent 0,
236, 202. 2003 Dec 25.
18. Tasset I, Pontes AJ, Hinojosa AJ, de la Torre R, Túnez I. Olive oil
reduces oxidative damage in a 3-nitropropionic acid-induced
Huntington’s disease-like rat model. Nutr Neurosci. 2011; 14:
106-11.
19. Brouillet E, Condé F, Beal MF, Hantraye P. Replicating
Huntington’s disease phenotype in experimental animals.
Prog Neurobiol. 1999; 9: 427-68.
20. Flohé L, Gunzler WA. Assay of glutathione peroxidase.
Methods Enzymol. 1984; 105: 114-121.
21. Sofi F, Macchi C, Abbate R, Gensini GF, Casini A. Effectiveness
of the Mediterranean diet: can it help dalay or prevent
Alzheimer’s disease? J Alzheimer Dis. 2010; 20: 795-801.
22. Alemany R. Navarro MA, Vögler O, Perona JS, Osada J,
Ruiz-Gutiérrez V. Olive oils modulate fatty acid content and
signalling protein expression in apolipoprotein E knockout
mice brain. Lipids. 2010; 45: 53-61.
23. Kumar P, Kalonia H, Kumar A. Nitric oxide mechanism in the
protective effect of antidepressants against 3-nitropropionic
acid-induced cognitive deficit, glutathine and mitochondrial
alterations in animal model of Huntington’s disease. Behav
Pharmacol. 2012; 21: 217-30.
24. Kumar P, Kumar A. Protective role of sertralina against
3-nitropropionc acid-induced ognitive dysfunction and redox
ratio in striatum, cortex and hippocampus of rat brain. Indian
J Exp Biol 2009; 47:715-22.
25. Silva RH, Abílio VC, Kameda SR, et al. Effects of
3-nitropropionic acid administration on memory and
hippocampal lipid peroxidation in sleep-deprived mice. Prog
Neuropsychopharmacol. Biol Psychiatry 2007; 31: 65-70.
26. Túnez I, Montilla P, Del Carmen Muñoz M, Feijóo M, Salcedo
M. Protective effect of melatonin on 3-nitropropionic acid-
induced oxidative stress in synaptosomes in an animal model
of Huntington’s disease. J Pineal Res. 2004; 37: 252-6.
27. Borlongan CV, Koutouzis TK, Sanberg PR. 3-Nitropropionic
acid animal model and Huntington’s disease. Neurosci Lett.
1998; 251: 173-6.
28. Brouillet E, Condé F, Beal MF, Hantraye P. Replicating
Huntington’s disease phenotype in experimental animals.
Pror Neurobiol. 1999; 59: 427-68.
29. de la Cruz JP, del Río S, Arrebola MM, López-Villodres JA,
Jebrouni N, González-Correa JA. Effect of virgin olive oil plus
acetylsalicylic acid on brain slices damage alter hypoxia-
reoxygenation in rats with type 1-like diabetes mellitus.
Neurosci Lett. 2010; 471: 89-93.
30. Rietjens SJ, Bast A, de Vente J, Haenen GR. The olive oil
antioxidant hydroxytyrosol efficiently protects against the
oxidative stress-induced impairment of the NO response of
isolated rat aorta. Am J Physiol Heart Circ Physiol. 2007; 292:
1931-36.
31. Tabernero A, Lavado EM, Granda B, Velasco A, Medina JM.
Neuronal differentiation is triggered by oleic acid synthesized
and released by astrocytes. J Neurochem. 2001; 79: 606-16.
32. Tello Hernández M de la V. Efectos del ácido oleico en la
migración neuronal y en la formación de sinapsis [tesis
doctoral]. Salamanca: Repositorio Documental Gredos,
Universidad de Salamanca; 2008.
33. Raederstorff D. Antioxidant activity of olive polyphenols in
humans: a review. Int J Vitam Nutr Res. 2010; 79: 152-65.
34. de la Torre R. Bioavailability of olive oil phenolic compounds in
humans. Inflammopharmacology. 2008; 16: 245-7.
35. Sandhir R, Mehrotra A, Kamboj SS. Lycopene prevents
3-nitropropionic mitochondrial oxidative stress and
dysfunctions in nervous system. Neurochem Int. 2010; 57:
579-87.
36. Kumar P, Paddi SS, Naidu PS, Kumar Al. Effect of resveratrol on
3-nitropropionic acid-induced biochemical and behavioural
changes: neutro protection mechanisms. Behav Pharmacol.
2006; 17: 485-92.